Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk
T Bhattacharyya, SJ Nicholls, EJ Topol, R Zhang… - Jama, 2008 - jamanetwork.com
Context Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective
properties. The relationship between PON1 genotypes and functional activity with systemic
measures of oxidative stress and cardiovascular disease (CVD) risk in humans has not been
systematically investigated. Objective To investigate the relationship of genetic and
biochemical determinants of PON1 activity with systemic measures of oxidative stress and
CVD risk in humans. Design, Setting, and Participants The association between systemic …
properties. The relationship between PON1 genotypes and functional activity with systemic
measures of oxidative stress and cardiovascular disease (CVD) risk in humans has not been
systematically investigated. Objective To investigate the relationship of genetic and
biochemical determinants of PON1 activity with systemic measures of oxidative stress and
CVD risk in humans. Design, Setting, and Participants The association between systemic …