Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study
CB Colen, N Seraji-Bozorgzad, B Marples… - …, 2006 - journals.lww.com
OBJECTIVE: To investigate a novel method to enhance radiosensitivity of gliomas via
modification of metabolite flux immediately before radiotherapy. Malignant gliomas are
highly glycolytic and produce copious amounts of lactic acid, which is effluxed to the tumor
microenvironment via lactate transporters. We hypothesized that inhibition of lactic acid
efflux would alter glioma metabolite profiles, including those that are radioprotective. 1 H
magnetic resonance spectroscopy (MRS) was used to quantify key metabolites, including …
modification of metabolite flux immediately before radiotherapy. Malignant gliomas are
highly glycolytic and produce copious amounts of lactic acid, which is effluxed to the tumor
microenvironment via lactate transporters. We hypothesized that inhibition of lactic acid
efflux would alter glioma metabolite profiles, including those that are radioprotective. 1 H
magnetic resonance spectroscopy (MRS) was used to quantify key metabolites, including …