[HTML][HTML] Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B
FG Haj, B Markova, LD Klaman, FD Bohmer… - Journal of Biological …, 2003 - ASBMB
Receptor tyrosine kinases (RTKs) are key regulators of cellular homeostasis. Based on in
vitro andex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was implicated in the
regulation of several RTKs, yet mice lacking PTP1B show defects mainly in insulin and leptin
receptor signaling. To address this apparent paradox, we studied RTK signaling in primary
and immortalized fibroblasts from PTP1B−/− mice. After growth factor treatment, cells lacking
PTP1B exhibit increased and sustained phosphorylation of the epidermal growth factor …
vitro andex vivo studies, protein tyrosine phosphatase-1B (PTP1B) was implicated in the
regulation of several RTKs, yet mice lacking PTP1B show defects mainly in insulin and leptin
receptor signaling. To address this apparent paradox, we studied RTK signaling in primary
and immortalized fibroblasts from PTP1B−/− mice. After growth factor treatment, cells lacking
PTP1B exhibit increased and sustained phosphorylation of the epidermal growth factor …