Exchange facilitated indirect detection of hyperpolarized 15ND2-amido-glutamine
AW Barb, SK Hekmatyar, JN Glushka… - Journal of Magnetic …, 2011 - Elsevier
Hyperpolarization greatly enhances opportunities to observe in vivo metabolic processes in
real time. Accessible timescales are, however, limited by nuclear spin relaxation times, and
sensitivity is limited by magnetogyric ratios of observed nuclei. The majority of applications
to date have involved direct 13C observation of metabolites with non-protonated carbons at
sites of interest (13C enriched carbonyls, for example), a choice that extends relaxation
times and yields moderate sensitivity. Interest in 15N containing metabolites is equally high …
real time. Accessible timescales are, however, limited by nuclear spin relaxation times, and
sensitivity is limited by magnetogyric ratios of observed nuclei. The majority of applications
to date have involved direct 13C observation of metabolites with non-protonated carbons at
sites of interest (13C enriched carbonyls, for example), a choice that extends relaxation
times and yields moderate sensitivity. Interest in 15N containing metabolites is equally high …