[HTML][HTML] Cleavage of automodified poly (ADP-ribose) polymerase during apoptosis: evidence for involvement of caspase-7
The abundant nuclear enzyme poly (ADP-ribose) polymerase (PARP) synthesizes poly
(ADP-ribose) in response to DNA strand breaks. During almost all forms of apoptosis, PARP
is cleaved by caspases, suggesting the crucial role of its inactivation. A few studies have
also reported a stimulation of PARP during apoptosis. However, the role of PARP stimulation
and cleavage during this cell death process remains poorly understood. Here, we measured
the stimulation of endogenous poly (ADP-ribose) synthesis during VP-16-induced apoptosis …
(ADP-ribose) in response to DNA strand breaks. During almost all forms of apoptosis, PARP
is cleaved by caspases, suggesting the crucial role of its inactivation. A few studies have
also reported a stimulation of PARP during apoptosis. However, the role of PARP stimulation
and cleavage during this cell death process remains poorly understood. Here, we measured
the stimulation of endogenous poly (ADP-ribose) synthesis during VP-16-induced apoptosis …