Differential caspase-3 expression in noncancerous, premalignant and cancer tissues of stomach and its clinical implication
Y Sun, XY Chen, J Liu, XX Cheng, XW Wang… - Cancer Detection and …, 2006 - Elsevier
BACKGROUND: Caspase-3 is a critical apoptosis-promoting element but its status during
stepwise gastrocarcinogenesis needs to be further clarified. Materials and methods: By the
use of frozen tissue microarrays constructed with the tissue spots cored from defined
histological regions in tissue blocks, the pattern of caspase-3 expression in noncancerous,
premalignant (atrophic gastritis and intestinal metaplasia) tissue and cancer spots were
analyzed under the same experimental conditions by the methods of immunohistochemistry …
stepwise gastrocarcinogenesis needs to be further clarified. Materials and methods: By the
use of frozen tissue microarrays constructed with the tissue spots cored from defined
histological regions in tissue blocks, the pattern of caspase-3 expression in noncancerous,
premalignant (atrophic gastritis and intestinal metaplasia) tissue and cancer spots were
analyzed under the same experimental conditions by the methods of immunohistochemistry …