Urea biosynthesis I. The urea cycle and relationships to the citric acid cycle
GE Shambaugh III - The American journal of clinical nutrition, 1977 - Elsevier
The urea cycle consist of five enzymatically controlled steps that are catalyzed by carbamyl
phosphate synthetase, ornithine transcarbamylase, argininosuccinate synthetase,
argininosuccinase, and arginase, respectively. The complete cycle is present in
physiological meaningful levels in the liver of terrestrial vertebrates, and in man represents
the sole mechanism for ammonia disposal. The formation of carbamyl phosphate and the
synthesis of argininosuccinate are potential limiting steps in urea biosynthesis but substrate …
phosphate synthetase, ornithine transcarbamylase, argininosuccinate synthetase,
argininosuccinase, and arginase, respectively. The complete cycle is present in
physiological meaningful levels in the liver of terrestrial vertebrates, and in man represents
the sole mechanism for ammonia disposal. The formation of carbamyl phosphate and the
synthesis of argininosuccinate are potential limiting steps in urea biosynthesis but substrate …