Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins
M Collin, A Olsén - Infection and immunity, 2001 - Am Soc Microbiol
M Collin, A Olsén
Infection and immunity, 2001•Am Soc MicrobiolStreptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as
well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades
IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on
native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity,
while EndoS is highly specific for IgG.
well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades
IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on
native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity,
while EndoS is highly specific for IgG.
Abstract
Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.
American Society for Microbiology