T cell, immunoglobulin domain and mucin domain-1 (TIM-1) is the nominant member of a
small family of related proteins that regulate immune cell activities. TIM-1 was initially
characterized in a mouse congenic analysis of Th2 T cell responses and related pathology.
Data accumulated to date suggest that TIM-1 regulates effector T cell function, and may play
distinct roles in the activities of B cells, invariant NKT cells and epithelial cells. In addition, a
variety of ligands for TIM-1 have been proposed. In this review I discuss recent data that …