[HTML][HTML] Specificity determinants in MAPK signaling to transcription factors
D Barsyte-Lovejoy, A Galanis, AD Sharrocks - Journal of Biological …, 2002 - ASBMB
One critical component in determining the specificity, fidelity, and efficiency of MAPK
substrate phosphorylation is the presence of distinct docking domains in the substrate
proteins. These docking domains are found in a range of substrates, including the
transcription factors myocyte enhancer factor-2A and SAP-1. However, the sequences of
these motifs differ, as does their targeting preferences by MAPKs, with SAP-1 being targeted
by both the ERK and p38 isoforms, whereas myocyte enhancer factor-2A is targeted only by …
substrate phosphorylation is the presence of distinct docking domains in the substrate
proteins. These docking domains are found in a range of substrates, including the
transcription factors myocyte enhancer factor-2A and SAP-1. However, the sequences of
these motifs differ, as does their targeting preferences by MAPKs, with SAP-1 being targeted
by both the ERK and p38 isoforms, whereas myocyte enhancer factor-2A is targeted only by …