Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma
A Shikotra, DF Choy, CM Ohri, E Doran, C Butler… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the
pathophysiology of asthma through 2 distinct pathways: a TSLP–OX40 ligand (OX40L)–T
cell axis and a TSLP–mast cell axis. Whether these pathways are active in human asthma is
unknown. OBJECTIVE: We sought to investigate whether mucosal TSLP protein expression
relates to asthma severity and distinct immunologic pathways. METHODS: In healthy
subjects and patients with mild-to-severe asthma, we immunostained bronchial biopsy …
pathophysiology of asthma through 2 distinct pathways: a TSLP–OX40 ligand (OX40L)–T
cell axis and a TSLP–mast cell axis. Whether these pathways are active in human asthma is
unknown. OBJECTIVE: We sought to investigate whether mucosal TSLP protein expression
relates to asthma severity and distinct immunologic pathways. METHODS: In healthy
subjects and patients with mild-to-severe asthma, we immunostained bronchial biopsy …