[HTML][HTML] Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes
Human innate immunity to non-pathogenic species of African trypanosomes is provided by
human high density lipoprotein (HDL) particles. Here we show that native human HDLs
containing haptoglobin-related protein (Hpr), apolipoprotein LI (apoL-I) and apolipoprotein
AI (apoA-I) are the principle antimicrobial molecules providing protection from trypanosome
infection. Other HDL subclasses containing either apoA-I and apoL-I or apoA-I and Hpr have
reduced trypanolytic activity, whereas HDL subclasses lacking apoL-I and Hpr are non-toxic …
human high density lipoprotein (HDL) particles. Here we show that native human HDLs
containing haptoglobin-related protein (Hpr), apolipoprotein LI (apoL-I) and apolipoprotein
AI (apoA-I) are the principle antimicrobial molecules providing protection from trypanosome
infection. Other HDL subclasses containing either apoA-I and apoL-I or apoA-I and Hpr have
reduced trypanolytic activity, whereas HDL subclasses lacking apoL-I and Hpr are non-toxic …