Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T …
HR Bohnenkamp, KT Papazisis, JM Burchell… - Cellular …, 2007 - Elsevier
Toll-like receptors (TLRs) recognise specific molecular signatures of pathogens and trigger
antimicrobial defence responses. Thereby, two independent signalling pathways can be
distinguished: The inflammatory signalling pathway acting via the adapter molecule MyD88,
leading to the activation of nuclear factor-κB (NF-κB) and mitogen activated protein kinases
(MAPK) such as SAPK/JNK and p38 MAPK and the interferon (IFN) dependent pathway that
signals via TRIF and results in the production of IFN-α/β. Several evolutionarily conserved …
antimicrobial defence responses. Thereby, two independent signalling pathways can be
distinguished: The inflammatory signalling pathway acting via the adapter molecule MyD88,
leading to the activation of nuclear factor-κB (NF-κB) and mitogen activated protein kinases
(MAPK) such as SAPK/JNK and p38 MAPK and the interferon (IFN) dependent pathway that
signals via TRIF and results in the production of IFN-α/β. Several evolutionarily conserved …