Noise-induced changes in gene expression in the cochleae of mice differing in their susceptibility to noise damage
MA Gratton, A Eleftheriadou, J Garcia, E Verduzco… - Hearing research, 2011 - Elsevier
The molecular mechanisms underlying the vast differences between individuals in their
susceptibility to noise-induced hearing loss (NIHL) are unknown. The present study
demonstrated that the effects of noise over-exposure on the expression of molecules likely to
be important in the development of NIHL differ among inbred mouse strains having distinct
susceptibilities to NIHL including B6 (B6. CAST) and 129 (129X1/SvJ and 129S1/SvImJ)
mice. The noise-exposure protocol produced a loss of 40 dB in hearing sensitivity in …
susceptibility to noise-induced hearing loss (NIHL) are unknown. The present study
demonstrated that the effects of noise over-exposure on the expression of molecules likely to
be important in the development of NIHL differ among inbred mouse strains having distinct
susceptibilities to NIHL including B6 (B6. CAST) and 129 (129X1/SvJ and 129S1/SvImJ)
mice. The noise-exposure protocol produced a loss of 40 dB in hearing sensitivity in …