The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention
L Kopelovich, JR Fay, CC Sigman, JA Crowell - … Epidemiology Biomarkers & …, 2007 - AACR
L Kopelovich, JR Fay, CC Sigman, JA Crowell
Cancer Epidemiology Biomarkers & Prevention, 2007•AACRThe mammalian target of rapamycin (mTOR) is a key signaling node coordinating cell cycle
progression and cell growth in response to genetic, epigenetic, and environmental
conditions. Pathways involved in mTOR signaling are dysregulated in precancerous human
tissues. These findings, together with the intriguing possibility that mTOR suppression may
be associated with antitumor actions of caloric restriction, suggest that mTOR signaling may
be an important target for chemopreventive drugs.(Cancer Epidemiol Biomarkers Prev 2007; …
progression and cell growth in response to genetic, epigenetic, and environmental
conditions. Pathways involved in mTOR signaling are dysregulated in precancerous human
tissues. These findings, together with the intriguing possibility that mTOR suppression may
be associated with antitumor actions of caloric restriction, suggest that mTOR signaling may
be an important target for chemopreventive drugs.(Cancer Epidemiol Biomarkers Prev 2007; …
Abstract
The mammalian target of rapamycin (mTOR) is a key signaling node coordinating cell cycle progression and cell growth in response to genetic, epigenetic, and environmental conditions. Pathways involved in mTOR signaling are dysregulated in precancerous human tissues. These findings, together with the intriguing possibility that mTOR suppression may be associated with antitumor actions of caloric restriction, suggest that mTOR signaling may be an important target for chemopreventive drugs. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1330–40)
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