[HTML][HTML] Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β

G von Gersdorff, K Susztak, F Rezvani, M Bitzer… - Journal of Biological …, 2000 - ASBMB
Smad7 is an inducible intracellular inhibitor of transforming growth factor-β (TGF-β)
signaling that is regulated by diverse stimuli including members of the TGF-β superfamily. To
define the molecular mechanisms of negative control of TGF-β signaling, we have isolated
the human SMAD7 gene and characterized its promoter region. A− 303 to+ 672 SMAD7
region contained a palindromic GTCTAGAC Smad binding element (SBE) between
nucleotides− 179 and− 172 that was necessary for the induction of a Smad7 promoter …