Transforming growth factor β (TGFβ) signaling has an increasing interest in regenerative
medicine as a potential tool to repair cartilages, however the chondrogenic effect of this
pathway in developing systems is controversial. Here we have analyzed the function of
TGFβ signaling in the differentiation of the developing limb mesoderm in vivo and in high
density micromass cultures. In these systems highest signaling activity corresponded with
cells at stages preceding overt chondrocyte differentiation. Interestingly treatments with …