Signal transduction by bone morphogenetic proteins
M Kawabata, T Imamura, K Miyazono - Cytokine & growth factor reviews, 1998 - Elsevier
Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which are members of
the transforming growth factor-β (TGF-β) superfamily. Activities of BMPs are extracellularly
regulated by BMP-binding proteins, Noggin and Chordin. BMPs bind to two different types of
serine-threonine kinase receptors, type I and type II. Two BMP type I receptors and a BMP
type II receptor have been identified in mammals. Intracellular signals are transduced by
Smad proteins. Smad1, Smad5 and probably MADH6, are activated by BMP receptors, form …
the transforming growth factor-β (TGF-β) superfamily. Activities of BMPs are extracellularly
regulated by BMP-binding proteins, Noggin and Chordin. BMPs bind to two different types of
serine-threonine kinase receptors, type I and type II. Two BMP type I receptors and a BMP
type II receptor have been identified in mammals. Intracellular signals are transduced by
Smad proteins. Smad1, Smad5 and probably MADH6, are activated by BMP receptors, form …