FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
M Peiseler, M Sebode, B Franke, F Wortmann… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: The pathogenesis of autoimmune hepatitis (AIH) is not understood,
but it was suggested that AIH may be related to a numerical or functional impairment of
CD4+ CD25+ FOXP3+ regulatory T cells (Treg), which are important mediators of immune
tolerance to self-antigens. However, the role of Treg in AIH is not clear, since earlier studies
reporting Treg impairment had used only CD25 as marker that cannot unambiguously
distinguish Treg from activated effector T cells. METHODS: We assessed the frequency and …
but it was suggested that AIH may be related to a numerical or functional impairment of
CD4+ CD25+ FOXP3+ regulatory T cells (Treg), which are important mediators of immune
tolerance to self-antigens. However, the role of Treg in AIH is not clear, since earlier studies
reporting Treg impairment had used only CD25 as marker that cannot unambiguously
distinguish Treg from activated effector T cells. METHODS: We assessed the frequency and …