[HTML][HTML] Estrogen signals to the preservation of endothelial cell form and function
M Razandi, A Pedram, ER Levin - Journal of Biological Chemistry, 2000 - ASBMB
Estrogen is important for the primary prevention of vascular disease in young women, but
the mechanisms of protection at the vascular cell are still largely unknown. Although
traditionally thought of as a nuclear transcription factor, the estrogen receptor has also been
identified in the cell plasma membrane to signal but serve largely undefined roles. Here we
show that estradiol (E2) rapidly activates p38β mitogen-activated protein kinase in
endothelial cells (EC), which activates the mitogen-activated protein kinase-activated protein …
the mechanisms of protection at the vascular cell are still largely unknown. Although
traditionally thought of as a nuclear transcription factor, the estrogen receptor has also been
identified in the cell plasma membrane to signal but serve largely undefined roles. Here we
show that estradiol (E2) rapidly activates p38β mitogen-activated protein kinase in
endothelial cells (EC), which activates the mitogen-activated protein kinase-activated protein …