The liver X receptor gene team: potential new players in atherosclerosis
JJ Repa, DJ Mangelsdorf - Nature medicine, 2002 - nature.com
JJ Repa, DJ Mangelsdorf
Nature medicine, 2002•nature.comLiver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression
of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal
cholesterol levels has implicated the involvement of LXR-induced genes in the
pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets
may provide alternative therapeutic strategies for the management of this disease.
of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal
cholesterol levels has implicated the involvement of LXR-induced genes in the
pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets
may provide alternative therapeutic strategies for the management of this disease.
Liver X receptors (LXRs) are sterol-responsive transcription factors that regulate expression of genes involved in cholesterol metabolism and homeostasis. Maintenance of normal cholesterol levels has implicated the involvement of LXR-induced genes in the pathophysiology of atherosclerosis. The modulation of LXRs or their downstream targets may provide alternative therapeutic strategies for the management of this disease.
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