[HTML][HTML] Rhodocytin (aggretin) activates platelets lacking α2β1 integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibα
W Bergmeier, D Bouvard, JA Eble… - Journal of Biological …, 2001 - ASBMB
Although α 2 β 1 integrin (glycoprotein Ia/IIa) has been established as a platelet collagen
receptor, its role in collagen-induced platelet activation has been controversial. Recently, it
has been demonstrated that rhodocytin (also termed aggretin), a snake venom toxin purified
from the venom ofCalloselasma rhodostoma, induces platelet activation that can be blocked
by monoclonal antibodies against α 2 β 1 integrin. This finding suggested that clustering of α
2 β 1 integrin by rhodocytin is sufficient to induce platelet activation and led to the hypothesis …
receptor, its role in collagen-induced platelet activation has been controversial. Recently, it
has been demonstrated that rhodocytin (also termed aggretin), a snake venom toxin purified
from the venom ofCalloselasma rhodostoma, induces platelet activation that can be blocked
by monoclonal antibodies against α 2 β 1 integrin. This finding suggested that clustering of α
2 β 1 integrin by rhodocytin is sufficient to induce platelet activation and led to the hypothesis …