[HTML][HTML] Platelet‐based coagulation: different populations, different functions
JWM Heemskerk, NJA Mattheij, J Cosemans - Journal of Thrombosis and …, 2013 - Elsevier
Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of
platelets can be distinguished: control of thrombin generation, support of fibrin formation,
and regulation of fibrin clot retraction. Here, we postulate that different populations of
platelets with distinct surface properties are involved in these coagulant functions. Platelets
with elevated Ca 2+ and exposed phosphatidylserine control thrombin and fibrin generation …
coagulation. In the concept of cell‐based control of coagulation, three different roles of
platelets can be distinguished: control of thrombin generation, support of fibrin formation,
and regulation of fibrin clot retraction. Here, we postulate that different populations of
platelets with distinct surface properties are involved in these coagulant functions. Platelets
with elevated Ca 2+ and exposed phosphatidylserine control thrombin and fibrin generation …