[HTML][HTML] Angiopoietin-2 stimulation of endothelial cells induces αvβ3 integrin internalization and degradation
M Thomas, M Felcht, K Kruse, S Kretschmer… - Journal of Biological …, 2010 - ASBMB
The angiopoietins (Ang-1 and Ang-2) have been identified as agonistic and antagonistic
ligands of the endothelial receptor tyrosine kinase Tie2, respectively. Both ligands have
been demonstrated to induce translocation of Tie2 to cell-cell junctions. However, only Ang-
1 induces Tie2-dependent Akt activation and subsequent survival signaling and endothelial
quiescence. Ang-2 interferes negatively with Ang-1/Tie2 signaling, thereby antagonizing the
Ang-1/Tie2 axis. Here, we show that both Ang-1 and Ang-2 recruit β3 integrins to Tie2. This …
ligands of the endothelial receptor tyrosine kinase Tie2, respectively. Both ligands have
been demonstrated to induce translocation of Tie2 to cell-cell junctions. However, only Ang-
1 induces Tie2-dependent Akt activation and subsequent survival signaling and endothelial
quiescence. Ang-2 interferes negatively with Ang-1/Tie2 signaling, thereby antagonizing the
Ang-1/Tie2 axis. Here, we show that both Ang-1 and Ang-2 recruit β3 integrins to Tie2. This …