Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth
ML Fishel, Y He, AM Reed, H Chin-Sinex, GD Hutchins… - DNA repair, 2008 - Elsevier
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein
with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER)
pathway and a reduction–oxidation (redox) signaling factor maintaining transcription factors
in an active reduced state. Our laboratory previously demonstrated that Ape1 is
overexpressed in ovarian cancer and potentially contributes to resistance. Therefore, we
utilized siRNA technology to knockdown protein levels of Ape1 in ovarian cancer cell line …
with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER)
pathway and a reduction–oxidation (redox) signaling factor maintaining transcription factors
in an active reduced state. Our laboratory previously demonstrated that Ape1 is
overexpressed in ovarian cancer and potentially contributes to resistance. Therefore, we
utilized siRNA technology to knockdown protein levels of Ape1 in ovarian cancer cell line …