[HTML][HTML] Regulation of the insulin gene by glucose and fatty acids
V Poitout, D Hagman, R Stein, I Artner… - The Journal of …, 2006 - Elsevier
The insulin gene is expressed almost exclusively in pancreatic β-cells. Metabolic regulation
of insulin gene expression enables the β-cell to maintain adequate stores of intracellular
insulin to sustain the secretory demand. Glucose is the major physiologic regulator of insulin
gene expression; it coordinately controls the recruitment of transcription factors [eg,
pancreatic/duodenal homeobox-1 (PDX-1), mammalian homologue of avian MafA/L-Maf
(MafA), Beta2/Neuro D (B2), the rate of transcription, and the stability of insulin mRNA …
of insulin gene expression enables the β-cell to maintain adequate stores of intracellular
insulin to sustain the secretory demand. Glucose is the major physiologic regulator of insulin
gene expression; it coordinately controls the recruitment of transcription factors [eg,
pancreatic/duodenal homeobox-1 (PDX-1), mammalian homologue of avian MafA/L-Maf
(MafA), Beta2/Neuro D (B2), the rate of transcription, and the stability of insulin mRNA …