Transient myeloproliferative disorder (transient leukemia) and hematologic manifestations of Down syndrome
Z Alvin, EJ Brown, C Hilary, D John - Clinics in laboratory medicine, 1999 - Elsevier
Transient Myeloproliferative Disorder (Transient Leukemia) is found in approximately 10% of
newborn infants with Down Syndrome. It is characterized by the large numbers of
megakaryo-blasts in the peripheral blood, variable thrombocytopenia and, in a minority of
cases, by a lethal course with hydrops fetalis or progressive hepatic fibrosis. Evidence is
presented that this disease is truly leukemia, which, in most cases, recovers spontaneously.
There is evidence that hematopoiesis is abnormal in Down Syndrome children who do not …
newborn infants with Down Syndrome. It is characterized by the large numbers of
megakaryo-blasts in the peripheral blood, variable thrombocytopenia and, in a minority of
cases, by a lethal course with hydrops fetalis or progressive hepatic fibrosis. Evidence is
presented that this disease is truly leukemia, which, in most cases, recovers spontaneously.
There is evidence that hematopoiesis is abnormal in Down Syndrome children who do not …