Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm
NR London, DY Li - Current opinion in hematology, 2011 - journals.lww.com
NR London, DY Li
Current opinion in hematology, 2011•journals.lww.comSummary Through harnessing Robo4-dependent Slit signaling, survival can be enhanced in
mouse models of sepsis and avian flu infection. This effect is achieved by blunting the host
vascular response to cytokines. Thus, vascular stabilizing programs should be investigated
as potential therapeutics for infectious disease characterized by cytokine storm.
mouse models of sepsis and avian flu infection. This effect is achieved by blunting the host
vascular response to cytokines. Thus, vascular stabilizing programs should be investigated
as potential therapeutics for infectious disease characterized by cytokine storm.
Summary
Through harnessing Robo4-dependent Slit signaling, survival can be enhanced in mouse models of sepsis and avian flu infection. This effect is achieved by blunting the host vascular response to cytokines. Thus, vascular stabilizing programs should be investigated as potential therapeutics for infectious disease characterized by cytokine storm.
Lippincott Williams & Wilkins