BACKGROUND: Ghrelin is a potent orexigenic hormone that likely impacts eating via
several mechanisms. Here, we hypothesized that ghrelin can regulate extra homeostatic,
hedonic aspects of eating behavior. METHODS: In the current study, we assessed the effects
of different pharmacological, physiological, and genetic models of increased ghrelin and/or
ghrelin-signaling blockade on two classic behavioral tests of reward behavior: conditioned
place preference (CPP) and operant conditioning. RESULTS: Using both CPP and operant …