[HTML][HTML] The zinc finger protein CTCF binds to the APBβ domain of the amyloid β-protein precursor promoter: evidence for a role in transcriptional activation

AA Vostrov, WW Quitschke - Journal of Biological Chemistry, 1997 - ASBMB
The promoter of the amyloid β-protein precursor (APP) gene directs high levels of cell type-
specific transcription with 94 base pairs 5′ to the main transcriptional start site. An essential
activator domain in this proximal APP promoter is a nuclear factor binding site designated as
APBβ. The recognition domain for the APBβ binding factor is located between position− 93
and− 82 relative to the main transcriptional start site. The nuclear factor that binds to the
APBβ site was partially purified by multiple steps of ion exchange and hydroxyapatite …