Granulocyte colony-stimulating factor (G-CSF) administration in individuals with sickle cell disease: time for a moratorium?
CD Fitzhugh, MM Hsieh, CD Bolan, C Saenz… - Cytotherapy, 2009 - Elsevier
Granulocyte colony-stimulating factor (G-CSF) is used commonly in an attempt to reduce the
duration of neutropenia and hospitalization in patients undergoing chemotherapy and to
obtain hematopoietic stem cells (HSC) for transplantation applications. Despite the relative
safety of administration of G-CSF in most individuals, including subjects with sickle cell trait,
severe and life-threatening complications have been reported when used in individuals with
sickle cell disease (SCD), including those who were asymptomatic and undiagnosed prior to …
duration of neutropenia and hospitalization in patients undergoing chemotherapy and to
obtain hematopoietic stem cells (HSC) for transplantation applications. Despite the relative
safety of administration of G-CSF in most individuals, including subjects with sickle cell trait,
severe and life-threatening complications have been reported when used in individuals with
sickle cell disease (SCD), including those who were asymptomatic and undiagnosed prior to …