[HTML][HTML] Integrin α6β4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes
E Hintermann, N Yang, D O'Sullivan… - Journal of Biological …, 2005 - ASBMB
Keratinocyte integrins α6β4 and α3β1 bind laminin-5, a component of basement
membranes. We previously demonstrated that in keratinocytes, haptotactic migration on
laminin-5 was stimulated by anti-β1 integrin-activating antibody TS2/16, whereas antibodies
to α6 and β4, respectively, blocked TS2/16-induced, α3β1-dependent migration. Moreover,
α6β4-associated haptotaxis inhibition was linked to a phosphatidylinositol 3-kinase (PI3K)
pathway and required erbB2 activation. erbB2, the ligand-less member of the epidermal …
membranes. We previously demonstrated that in keratinocytes, haptotactic migration on
laminin-5 was stimulated by anti-β1 integrin-activating antibody TS2/16, whereas antibodies
to α6 and β4, respectively, blocked TS2/16-induced, α3β1-dependent migration. Moreover,
α6β4-associated haptotaxis inhibition was linked to a phosphatidylinositol 3-kinase (PI3K)
pathway and required erbB2 activation. erbB2, the ligand-less member of the epidermal …