[HTML][HTML] Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis
LE Gomez-Quiroz, VM Factor, P Kaposi-Novak… - Journal of biological …, 2008 - ASBMB
The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction
pathway that controls cell survival. We previously demonstrated that mice lacking c-Met (Met-
KO) in hepatocytes were hypersensitive to Fas-induced liver injury. In this study, we used
primary hepatocytes isolated from Met-KO and control (Cre-Ctrl) mice to address more
directly the protective effects of c-Met signaling. Loss of c-Met function increased sensitivity
to Fas-mediated apoptosis. Hepatocyte growth factor suppressed apoptosis in Cre-Ctrl but …
pathway that controls cell survival. We previously demonstrated that mice lacking c-Met (Met-
KO) in hepatocytes were hypersensitive to Fas-induced liver injury. In this study, we used
primary hepatocytes isolated from Met-KO and control (Cre-Ctrl) mice to address more
directly the protective effects of c-Met signaling. Loss of c-Met function increased sensitivity
to Fas-mediated apoptosis. Hepatocyte growth factor suppressed apoptosis in Cre-Ctrl but …