[HTML][HTML] Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis: formation of these oxidized …

G Subbanagounder, JW Wong, H Lee, KF Faull… - Journal of Biological …, 2002 - ASBMB
Monocyte recruitment to the vessel wall, mediated by monocyte chemotactic protein-1 (MCP-
1) and interleukin-8 (IL-8), plays an important role in atherogenesis. We have shown
previously that minimally oxidized low density lipoprotein, oxidized 1-palmitoyl-2-
arachidonyl-sn-glycero-3-phosphorylcholine (Ox-PAPC), activates endothelial cells to
produce MCP-1 and IL-8. By using liquid chromatography/mass spectrometry methods
coupled with bioassay, we report a family of epoxyisoprostane (PEIPC) and …