Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
SH Soderling, LK Langeberg… - Proceedings of the …, 2003 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2003•National Acad Sciences
The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals
from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific
protein expressed in variety of areas including the regions of the hippocampus and the
Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice
with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent
learning and memory. These sensorimotor and cognitive deficits are analogous to the …
from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific
protein expressed in variety of areas including the regions of the hippocampus and the
Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice
with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent
learning and memory. These sensorimotor and cognitive deficits are analogous to the …
The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.
National Acad Sciences