Increased tissue or serum levels of oxidized phospholipids have been detected in a variety
of chronic and acute pathological conditions such as hyperlipidemia, atherosclerosis, heart
attack, cell apoptosis, acute inflammation and injury. We have recently described signaling
cascades activated by oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
(OxPAPC) in the human pulmonary artery endothelial cells (EC) and reported potent barrier-
protective effects of OxPAPC, which were mediated by small GTPases Rac and Cdc42. In …