Improved outcome of high-risk early HER2 positive breast cancer with high CXCL13-CXCR5 messenger RNA expression
E Razis, KT Kalogeras, V Kotoula, AG Eleftheraki… - Clinical breast …, 2012 - Elsevier
Background Chemokines are important in cell migration and are thought to play a key role in
metastasis. We explored the prognostic significance of CXC ligand-motif (CXCL) 12,
CXCL13, and receptor (CXCR) 5 on disease-free survival (DFS) and overall survival (OS) in
early breast cancer. Methods A total of 595 patients at high risk for early breast cancer were
treated in a 2-arm trial (HE10/97) with dose-dense sequential epirubicin followed by
cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) with or without paclitaxel. RNA …
metastasis. We explored the prognostic significance of CXC ligand-motif (CXCL) 12,
CXCL13, and receptor (CXCR) 5 on disease-free survival (DFS) and overall survival (OS) in
early breast cancer. Methods A total of 595 patients at high risk for early breast cancer were
treated in a 2-arm trial (HE10/97) with dose-dense sequential epirubicin followed by
cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) with or without paclitaxel. RNA …