[HTML][HTML] UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE
ME Williams, P Strickland, K Watanabe… - Journal of Biological …, 2003 - ASBMB
The UNC5Hs are axon guidance receptors that mediate netrin-1-dependent
chemorepulsion, and dependence receptors that mediate netrin-1-independent apoptosis.
Here, we report an interaction between UNC5H1 and NRAGE. Our experiments show that
this interaction is responsible for apoptosis induced by UNC5H1, and this level of apoptosis
is greater than the amount induced by either UNC5H2 or UNC5H3. We mapped the NRAGE
binding domain of UNC5H1 to its ZU-5 domain and show that this region, in addition to an …
chemorepulsion, and dependence receptors that mediate netrin-1-independent apoptosis.
Here, we report an interaction between UNC5H1 and NRAGE. Our experiments show that
this interaction is responsible for apoptosis induced by UNC5H1, and this level of apoptosis
is greater than the amount induced by either UNC5H2 or UNC5H3. We mapped the NRAGE
binding domain of UNC5H1 to its ZU-5 domain and show that this region, in addition to an …