Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog
C Thibert, MA Teillet, F Lapointe, L Mazelin… - Science, 2003 - science.org
C Thibert, MA Teillet, F Lapointe, L Mazelin, NM Le Douarin, P Mehlen
Science, 2003•science.orgDuring early development in vertebrates, Sonic hedgehog (Shh) is produced by the
notochord and the floor plate. A ventrodorsal gradient of Shh directs ventrodorsal patterning
of the neural tube. However, Shh is also required for the survival of neuroepithelial cells. We
show that Patched (Ptc) induces apoptotic cell death unless its ligand Shh is present to block
the signal. Moreover, the blockade of Ptc-induced cell death partly rescues the chick spinal
cord defect provoked by Shh deprivation. Thus, the proapoptotic activity of unbound Ptc and …
notochord and the floor plate. A ventrodorsal gradient of Shh directs ventrodorsal patterning
of the neural tube. However, Shh is also required for the survival of neuroepithelial cells. We
show that Patched (Ptc) induces apoptotic cell death unless its ligand Shh is present to block
the signal. Moreover, the blockade of Ptc-induced cell death partly rescues the chick spinal
cord defect provoked by Shh deprivation. Thus, the proapoptotic activity of unbound Ptc and …
During early development in vertebrates, Sonic hedgehog (Shh) is produced by the notochord and the floor plate. A ventrodorsal gradient of Shh directs ventrodorsal patterning of the neural tube. However, Shh is also required for the survival of neuroepithelial cells. We show that Patched (Ptc) induces apoptotic cell death unless its ligand Shh is present to block the signal. Moreover, the blockade of Ptc-induced cell death partly rescues the chick spinal cord defect provoked by Shh deprivation. Thus, the proapoptotic activity of unbound Ptc and the positive effect of Shh-bound Ptc on cell differentiation probably cooperate to achieve the appropriate spinal cord development.
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