Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans
ED Marczak, J Marzec, DC Zeldin… - Pharmacogenetics …, 2012 - journals.lww.com
Objective Oxidative stress is integral to the development of endothelial dysfunction and
cardiovascular disease. As NRF2 is a key transcription factor in antioxidant defense, we
aimed to determine whether polymorphisms within the promoter region of the gene
encoding NRF2 (NFE2L2) would significantly modify vasodilator responses in humans.
Methods Associations between the− 653A/G (rs35652124),− 651G/A (rs6706649), and−
617C/A (rs6721961) polymorphisms within the NFE2L2 promoter and vascular function …
cardiovascular disease. As NRF2 is a key transcription factor in antioxidant defense, we
aimed to determine whether polymorphisms within the promoter region of the gene
encoding NRF2 (NFE2L2) would significantly modify vasodilator responses in humans.
Methods Associations between the− 653A/G (rs35652124),− 651G/A (rs6706649), and−
617C/A (rs6721961) polymorphisms within the NFE2L2 promoter and vascular function …