Hypomethylation of ras oncogenes in primary human cancers
AP Feinberg, B Vogelstein - Biochemical and biophysical research …, 1983 - Elsevier
Biochemical and biophysical research communications, 1983•Elsevier
We have examined the methylation status of two cellular oncogenes, c-Ha-ras and c-Ki-ras,
in primary human carcinomas and the adjacent analogous normal tissues from which the
tumors derived. The c-Ha-ras gene was hypomethylated in six of eight carcinomas, including
five colonic adenocarcinomas and one small cell lung carcinoma, when compared to
adjacent normal tissues. The c-Ki-ras gene was hypomethylated to a lesser extent in two
colonic adenocarcinomas. This is the first demonstration of alterations in methylation of …
in primary human carcinomas and the adjacent analogous normal tissues from which the
tumors derived. The c-Ha-ras gene was hypomethylated in six of eight carcinomas, including
five colonic adenocarcinomas and one small cell lung carcinoma, when compared to
adjacent normal tissues. The c-Ki-ras gene was hypomethylated to a lesser extent in two
colonic adenocarcinomas. This is the first demonstration of alterations in methylation of …
Summary
We have examined the methylation status of two cellular oncogenes, c-Ha-ras and c-Ki-ras, in primary human carcinomas and the adjacent analogous normal tissues from which the tumors derived. The c-Ha-ras gene was hypomethylated in six of eight carcinomas, including five colonic adenocarcinomas and one small cell lung carcinoma, when compared to adjacent normal tissues. The c-Ki-ras gene was hypomethylated to a lesser extent in two colonic adenocarcinomas. This is the first demonstration of alterations in methylation of cellular oncogenes in human cancer.
Elsevier