[HTML][HTML] Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
T Oka, V Mazack, M Sudol - Journal of Biological Chemistry, 2008 - ASBMB
The Hippo pathway in Drosophila controls the size and shape of organs. In the fly, activation
of this pathway conveys growth-inhibitory signals and promotes apoptosis in epithelial cells.
We" reconstituted" the Hippo pathway in a human epithelial cell line and showed that, in
contrast to flies, the activation of this pathway results in anti-apoptotic signals. We have
shown that in human embryonic kidney (HEK) 293 cells, the complex formation between
transcriptional co-activators YAPs (Yes kinase-associated proteins) and Lats kinases …
of this pathway conveys growth-inhibitory signals and promotes apoptosis in epithelial cells.
We" reconstituted" the Hippo pathway in a human epithelial cell line and showed that, in
contrast to flies, the activation of this pathway results in anti-apoptotic signals. We have
shown that in human embryonic kidney (HEK) 293 cells, the complex formation between
transcriptional co-activators YAPs (Yes kinase-associated proteins) and Lats kinases …