[HTML][HTML] Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells

T Ueda, NR Mawji, N Bruchovsky, MD Sadar - Journal of Biological …, 2002 - ASBMB
The androgen receptor (AR) can be activated in the absence of androgens by interleukin-6
(IL-6) in human prostate cancer cells. The events involved in ligand-independent activation
of the AR are unknown, but have been suggested to involve phosphorylation of the AR itself
or a receptor-associated protein. Steroid receptor coactivator-1 (SRC-1) has been shown to
interact with the human AR and to modulate ligand-dependent AR transactivation and is
regulated by phosphorylation by MAPK. To date, no one has examined the role of SRC-1 in …