[HTML][HTML] Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal …
MD Sadar - Journal of Biological Chemistry, 1999 - ASBMB
Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens
in advanced prostate cancer. To determine the molecular mechanism (s) of androgen-
independent regulation of the PSA gene, the possibility that the androgen receptor (AR) is
activated in the absence of androgen by stimulation of protein kinase A (PKA) was
investigated. Activation of PKA by forskolin resulted in elevated expression of the PSA gene
in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen …
in advanced prostate cancer. To determine the molecular mechanism (s) of androgen-
independent regulation of the PSA gene, the possibility that the androgen receptor (AR) is
activated in the absence of androgen by stimulation of protein kinase A (PKA) was
investigated. Activation of PKA by forskolin resulted in elevated expression of the PSA gene
in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen …