[HTML][HTML] Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation: influence of structure-stabilizing solutes and protein …
J Reid, SM Kelly, K Watt, NC Price… - Journal of Biological …, 2002 - ASBMB
The androgen receptor (AR) is a member of the nuclear receptor superfamily. Sequences
within the large amino-terminal domain of the receptor have been shown to be important for
transactivation and protein-protein interactions; however, little is known about the structure
and folding of this region. In the present study we show that a 344-amino acid polypeptide
representing the main determinants for transactivation has the propensity to form α-helical
structure and that mutations which disrupt putative helical regions alter conformation …
within the large amino-terminal domain of the receptor have been shown to be important for
transactivation and protein-protein interactions; however, little is known about the structure
and folding of this region. In the present study we show that a 344-amino acid polypeptide
representing the main determinants for transactivation has the propensity to form α-helical
structure and that mutations which disrupt putative helical regions alter conformation …