New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications
A Ahmed - Thrombosis research, 2011 - Elsevier
The incidence of preeclampsia is reduced by a third in smokers, but not in snuff users.
Soluble Flt-1 (sFlt-1) and soluble endoglin (sEng) are increased prior to the clinical onset of
preeclampsia. Animals exposed to high circulating levels of sFlt-1 and sEng elicit severe
preeclampsia-like symptoms. Smokers have reduced circulating sFlt-1 and cigarette smoke
extract decreases sFlt-1 release from placental villous explants. An anti-inflammatory
enzyme, heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO), inhibit sFlt-1 …
Soluble Flt-1 (sFlt-1) and soluble endoglin (sEng) are increased prior to the clinical onset of
preeclampsia. Animals exposed to high circulating levels of sFlt-1 and sEng elicit severe
preeclampsia-like symptoms. Smokers have reduced circulating sFlt-1 and cigarette smoke
extract decreases sFlt-1 release from placental villous explants. An anti-inflammatory
enzyme, heme oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO), inhibit sFlt-1 …