[HTML][HTML] SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: possible role in AMP-activated protein kinase activation
F Lan, JM Cacicedo, N Ruderman, Y Ido - Journal of Biological Chemistry, 2008 - ASBMB
SIRT1, a histone/protein deacetylase, and AMP-activated protein kinase (AMPK) are key
enzymes responsible for longevity and energy homeostasis. We examined whether a
mechanistic connection exists between these molecules that involves the major AMPK
kinase LKB1. Initial studies demonstrated that LKB1 is acetylated in cultured (HEK293T)
cells, mouse white adipose tissue, and rat liver. In the 293T cells, SIRT1 overexpression
diminished lysine acetylation of LKB1 and concurrently increased its activity …
enzymes responsible for longevity and energy homeostasis. We examined whether a
mechanistic connection exists between these molecules that involves the major AMPK
kinase LKB1. Initial studies demonstrated that LKB1 is acetylated in cultured (HEK293T)
cells, mouse white adipose tissue, and rat liver. In the 293T cells, SIRT1 overexpression
diminished lysine acetylation of LKB1 and concurrently increased its activity …