[HTML][HTML] Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and-independent pathways
N Kubota, Y Terauchi, T Kubota, H Kumagai… - Journal of Biological …, 2006 - ASBMB
* Thiazolidinediones have been shown to up-regulate adiponectin expression in white
adipose tissue and plasma adiponectin levels, and these up-regulations have been
proposed to be a major mechanism of the thiazolidinedione-induced amelioration of insulin
resistance linked to obesity. To test this hypothesis, we generated adiponectin knock-out
(adipo-/-) ob/ob mice with a C57B/6 background. After 14 days of 10 mg/kg pioglitazone, the
insulin resistance and diabetes of ob/ob mice were significantly improved in association with …
adipose tissue and plasma adiponectin levels, and these up-regulations have been
proposed to be a major mechanism of the thiazolidinedione-induced amelioration of insulin
resistance linked to obesity. To test this hypothesis, we generated adiponectin knock-out
(adipo-/-) ob/ob mice with a C57B/6 background. After 14 days of 10 mg/kg pioglitazone, the
insulin resistance and diabetes of ob/ob mice were significantly improved in association with …