[HTML][HTML] Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
XJ Xu, MS Gauthier, DT Hess, CM Apovian… - Journal of lipid …, 2012 - ASBMB
We previously reported that adenosine monophosphate-activated protein kinase (AMPK)
activity is lower in adipose tissue of morbidly obese individuals who are insulin resistant
than in comparably obese people who are insulin sensitive. However, the number of
patients and parameters studied were small. Here, we compared abdominal subcutaneous,
epiploic, and omental fat from 16 morbidly obese individuals classified as insulin sensitive or
insulin resistant based on the homeostatic model assessment of insulin resistance. We …
activity is lower in adipose tissue of morbidly obese individuals who are insulin resistant
than in comparably obese people who are insulin sensitive. However, the number of
patients and parameters studied were small. Here, we compared abdominal subcutaneous,
epiploic, and omental fat from 16 morbidly obese individuals classified as insulin sensitive or
insulin resistant based on the homeostatic model assessment of insulin resistance. We …