[HTML][HTML] The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the-343 G→ C polymorphism associated with …
M Olferiev, E Masuda, S Tanaka, MC Blank… - Journal of Biological …, 2007 - ASBMB
The inhibitory receptor FcγRIIb is a negative regulator of antibody production and
inflammatory responses. The-343 G→ C polymorphism in the human FCGR2B promoter is
associated with systemic lupus erythematosus. The-343 C mutant promoter has decreased
transcriptional activity. In the present study, we show that the transcriptional change
correlates with quantitative differences in the interaction of the activating protein 1 complex
with the mutant FCGR2B promoter. Promoter pulldown and chromatin immunoprecipitation …
inflammatory responses. The-343 G→ C polymorphism in the human FCGR2B promoter is
associated with systemic lupus erythematosus. The-343 C mutant promoter has decreased
transcriptional activity. In the present study, we show that the transcriptional change
correlates with quantitative differences in the interaction of the activating protein 1 complex
with the mutant FCGR2B promoter. Promoter pulldown and chromatin immunoprecipitation …